Table 4.
Comparison of patient and tumor characteristics by BRCA2 expression
| Characteristic | Number of patients |
Number with non-wild type BRCA2 (protein under- expression) |
Number with wild type BRCA2 (normal protein expression) |
p-value |
|---|---|---|---|---|
| Age at Diagnosis | ||||
| < 61 years | 22 | 4 (28.6%) | 18 (51.4%) | 0.1462a |
| ≥ 61 years | 27 | 10 (71.4%) | 17 (48.6%) | |
| Mean (years) | 60.0 | 62.6 (N = 14) | 58.9 (N = 35) | 0.4502b |
| Median (years) | 62 | 63.5 | 59 | |
| Tumor Grade | ||||
| I | 2 | 0 (0%) | 2 (5.9%) | 0.2072a |
| II | 37 | 11 (100%) | 26 (76.5%) | |
| III | 6 | 0 (0%) | 6 (17.7%) | |
| Laterality | ||||
| Right breast | 24 | 7 (63.6%) | 17 (51.5%) | 0.4844a |
| Left breast | 20 | 4 (36.4%) | 16 (48.5%) | |
| Both breasts | 0 | 0 (0%) | 0 (0%) | |
| Lymph Node Status | ||||
| Negative | 24 | 6 (46.1%) | 18 (52.9%) | 0.6771a |
| Positive | 23 | 7 (53.9%) | 16 (47.1%) | |
| ER Status | ||||
| Negative | 3 | 0 (0%) | 3 (21.4%) | 0.2593a |
| Positive | 16 | 5 (100%) | 11 (78.6%) | |
| PR Status | ||||
| Negative | 3 | 0 (0%) | 3 (23.1%) | 0.2393a |
| Positive | 15 | 15 | 10 (76.9%) | |
| Tumor Size (cm) | ||||
| < 3 cm | 12 | 4 (44.4%) | 8 (38.1%) | 0.7450a |
| ≥ 3 cm | 18 | 5 (55.6%) | 13 (61.9%) | |
| Androgen receptor CAG repeat Length | ||||
| < 20 | 21 | 5 (45.5%) | 16 (50%) | 0.7947a |
| ≥ 20 | 22 | 6 (54.6%) | 16 (50%) |
a
χ2-test.
b
t-test.