Table 1.
MiRNAs that have been reported associated with therapy resistance in NHL
| MiRNAs | Targets | NHL Types |
|---|---|---|
| Downregulation | ||
| miR-15a/16-1 | cyclinD1, MCL-1, BCL-2, BAI2A, RNF41, RASSF5, MKK3, LRIG1 | CLL, MCL, NK/TCL |
| miR-181b | TCL-1, BCL-2, MCL-1, AID, XIAP, FOXP1 | CLL, DLBCL |
| miR-29 | MCL-1, TCL-1, CDK6, IGF1R, DNMT3A, PXND | CLL, DLBCL, MCL, NK/TCL |
| miR-34a | SIRT1, FOXP1 | CLL, DLBCL, MCL |
| Up-regulation | ||
| miR-155 | SOCS1, SMAD5, SHIP1, PIK3R1 | CLL, DLBCL, BL, CTCL, NK/TCL |
| miR-21 | PTEN, PDCD4, CCND2, DPH1 | CLL, DLBCL, CTCL, NK/TCL |
| miR-221/222 | P27 | CLL, DLBCL |
| miR-17-92cluster | PTEN, PHLPP2, BIM, ITIME2F5, T53INP1, TRIM8, IBTB4 | CLL, DLBCL, MCL, BL |
| miR-148b | - | BL |
CLL: chronic lymphocytic leukemia; DLBCL: diffuse large B cell lymphoma; MCL: mantle cell lymphoma; BL: Burkitt’s lymphoma; CTCL: cutaneous T-Cell Lymphoma; NK/TCL NK/T-cell lymphoma.