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A. MDA-MB-231 cell invasion in random siRNA and HIF-1α-targeted siRNA groups. Cells were added into the upper chamber of Boyden chamber. When cells migrated through Matrigel and polycarbonate membrane after 24 h, the filtration membrane was treated, followed by routine hematoxylin & eosin staining. B. Quantification of the number of transmembrane cells. The data were expressed as means ± SEM. *, P < 0.05 compared with control.
