Figure 1.

Pivaloylacylation-7ADCA did not induce chromosome aberration in in mice bone marrow cells. The genotoxicity of Pivaloylacylation-7ADCA on chromosome level was assessed using the in vivo mouse micronucleus test. After treatment with different concentrations of pivaloylacylation-7ADCA, along with positive control cyclophosphamide (CP) and solvent control sodium carboxyl methyl cellulose (CMC-Na), mice were sacrificed. Then mice bone marrow smears were prepared, fixed, air dried and examined as described in the “Materials and Method” section. A. Illustrates the ratio of PCE/NCE. B. Illustrates the frequency of micronucleated cells. Data were obtained from three independent experiments and Poisson distribution was used to analyze the data. “a” denotes a significant difference in the frequency of micronucleated cells compared to the DMSO control group. Statistical significance was set as P<0.05.