Figure 2.

Pivaloylacylation-7ADCA failed to induce DNA damage in L5178Y mouse lymphoma cells. L5178Y mouse lymphoma cells were treated with pivaloylacylation-7ADCA, along with positive control MMS and solvent control DMSO. The effect of pivaloylacylation-7ADCA on DNA damage was assessed using the single cell gel electrophoresis assay. Tail intensity (% of tail DNA) and olive tail moment (OTM) were used as the qualitative and quantitative measurement of DNA damage. A. Represents the DMSO control. B. Represents the cells treated by 5000 μg/ml pivaloylacylation-7ADCA. C. Illustrates the cells treated by positive control methyl methane sulphonate (MMS, 5.0 μg/ml). D. Illustrates the tail intensity (% of tail DNA). E. Illustrates the OTM value. Data were obtained from three independent experiments and and were expressed as mean ± standard deviation (S.D.) Statistical significance was set as P<0.05.