Table 2.
The effects of pivaloylacylation-7ADCA on TK gene mutation
| Dose (μg/ml) | RV (%) | RSG (%) | RTG (%) | MF (×10-6) |
|---|---|---|---|---|
| 625 | 92.48 | 94.50 | 87.40 | 69.70 |
| 1250 | 82.95 | 89.13 | 73.93 | 80.37 |
| 2500 | 64.14 | 70.27 | 45.07 | 102.40 |
| 5000 | 57.57 | 56.63 | 32.60 | 133.33 |
| DMSO control | 100.00 | 100.00 | 100.00 | 77.90 |
| Positive control | 91.19 | 71.03 | 64.77 | 271.90a |
TK gene mutation test were performed to further detect whether or not pivaloylacylation-7ADCA caused gene mutation. Four dose of pivaloylacylation-7ADCA, along with positive control methyl methane sulphonate (MMS, 5 μg/ml) and solvent control 1‰ (ν/ν) DMSO were tested in this assay. The mutation frequency (MF) was expressed as the number of mutants per 106 viable cells.
a
indicates a significant difference in the value of MF compared to the solvent control group.
Statistical significance was set as P<0.05.