Table 3.
The polymorphisms of the integrin gene and the risk of BC
| Polymorphism | Patients (n = 317) | Controls (n = 317)a | OR (95%) | P value b | |||
|---|---|---|---|---|---|---|---|
|
|
|||||||
| n | % | n | % | ||||
| rs11902171 | GG (540) | 268 | 84.54 | 272 | 85.80 | 1 | - |
| GC (91) | 48 | 15.14 | 43 | 13.56 | 0.88 (0.57-1.38) | 0.58 | |
| CC (3) | 1 | 0.32 | 2 | 0.64 | 1.97 (0.18-21.86) | 1.00 | |
| G (1171) | 584 | 92.11 | 587 | 92.59 | 1 | - | |
| C (97) | 50 | 7.89 | 47 | 7.41 | 0.94 (0.62-1.42) | 0.75 | |
| rs2675b | AA (412) | 219 | 69.08 | 193 | 60.88 | 1 | - |
| AC (195) | 86 | 27.13 | 109 | 34.38 | 1.44 (1.02-2.03) | 0.04 | |
| CC (27) | 12 | 3.79 | 15 | 4.74 | 1.42 (0.65-3.11) | 0.38 | |
| A (1019) | 524 | 82.65 | 495 | 78.08 | 1 | - | |
| C (249) | 110 | 17.35 | 139 | 21.92 | 1.34 (1.01-1.77) | 0.04 | |
| rs17664 | GG (453) | 222 | 70.03 | 231 | 72.87 | 1 | - |
| GA (168) | 91 | 28.71 | 77 | 24.29 | 0.81 (0.57-1.16) | 0.25 | |
| AA (13) | 4 | 1.26 | 9 | 2.84 | 2.16 (0.66-7.12) | 0.31 | |
| G (1074) | 535 | 84.28 | 539 | 85.02 | |||
| A (195) | 99 | 15.62 | 95 | 14.98 | 0.95 (0.70-1.29) | 0.76 | |
| rs1062484 | CC (623) | 309 | 97.48 | 314 | 99.05 | 1 | - |
| CT (11) | 8 | 2.52 | 3 | 0.95 | 0.37 (0.10-1.40) | 0.22 | |
| C (1257) | 626 | 98.74 | 631 | 99.53 | |||
| T (11) | 8 | 1.26 | 3 | 0.47 | 0.37 (0.10-1.41) | 0.23 | |
a
Hardy-Weinberg equilibrium calculation for control subjects: p = 0.83 for rs11902171, p = 0.94 for rs2675, p = 0.41 for rs17664, p = 0.93 for rs1062484.
b
The bold numbers mean the p value is < 0.05.