Table 5.
Area under the ROC curves and 95% confidence intervals for WHtR, with cut-offs for the sensitivity, specificity, balanced accuracy, PPV, and PNV of individual MS components, hyperinsulinism, and HOMA-IR diagnosis.
| Variable | Area under the ROC curve (95% C.I.) | Significancea | Optimal cut-off pointb | Sensitivity | Specificity | Balanced accuracy | PPVc | PNVd |
|---|---|---|---|---|---|---|---|---|
| WHtR | ||||||||
| High TG overall | 0.600 (0.441–0.760) | P = 0.200 | 0.60 | 62.8% | 62.5% | 62.7% | 90.8% | 22.2% |
| High TG female | 0.581 (0.251–0.912) | P = 0.555 | 0.58 | 76.7% | 60.0% | 68.4% | 94.3% | 23.1% |
| High TG male | 0.622 (0.441–0.803) | P = 0.207 | 0.60 | 66.7% | 63.6% | 65.2% | 89.5% | 29.2% |
| Low HDL-C overall | 0.501 (0.389–0.613) | P = 0.985 | 0.63 | 43.9% | 63.6% | 53.8% | 64.4% | 43.1% |
| Low HDL-C female | 0.613 (0.451–0.774) | P = 0.188 | 0.60 | 64.3% | 55.0% | 59.7% | 66.7% | 52.4% |
| Low HDL-C male | 0.416 (0.269–0.562) | P = 0.266 | 0.63 | 42.1% | 54.2% | 48.2% | 59.3% | 37.1% |
| Hyperglycemia overall | 0.606 (0.335–0.877) | P = 0.426 | 0.65 | 60.0% | 69.5% | 64.8% | 8.6% | 97.3% |
| Hyperglycemia female | 0.689 (0.388–0.990) | P = 0.277 | 0.65 | 66.7% | 82.2% | 74.5% | 20.0% | 97.4% |
| Hyperglycemia male | 0.567 (0.009–1.000) | P = 0.750 | 0.76 | 50.0% | 93.3% | 71.7% | 20.0% | 98.3% |
| Hypertension overall | 0.601 (0.491–0.711) | P = 0.081 | 0.63 | 51.3% | 64.8% | 58.1% | 44.4% | 70.8% |
| Hypertension female | 0.737 (0.584–0.891) | P = 0.006e | 0.62 | 66.7% | 73.3% | 70.0% | 60.0% | 78.6% |
| Hypertension male | 0.512 (0.359–0.665) | P = 0.876 | 0.66 | 38.1% | 68.3% | 53.2% | 38.1% | 68.3% |
| Hyperinsulinism overall | 0.599 (0.490–0.780) | P = 0.093 | 0.61 | 69.4% | 52.7% | 61.1% | 41.7% | 78.0% |
| Hyperinsulinism female | 0.717 (0.569–0.865) | P = 0.014e | 0.61 | 70.6% | 64.5% | 67.6% | 52.2% | 80.0% |
| Hyperinsulinism male | 0.509 (0.358–0.660) | P = 0.909 | 0.61 | 68.4% | 44.2% | 56.3% | 35.1% | 76.0% |
| Insulin resistance (HOMA) overall | 0.566 (0.459–0.673) | P = 0.245 | 0.61 | 64.3% | 51.5% | 57.9% | 45.0% | 70.0% |
| Insulin resistance (HOMA) female | 0.713 (0.567–0.859) | P = 0.013e | 0.61 | 68.4% | 65.5% | 67.0% | 56.5% | 76.0% |
| Insulin resistance (HOMA) male | 0.457 (0.312–0.602) | P = 0.575 | 0.59 | 73.9% | 28.2% | 51.1% | 37.8% | 64.7% |
In all cases, 110 subjects (48 females and 62 males) were considered.
aNull hypothesis: area = 0.5.
bPositive if assessment is more than or equal to the optimal cut-off point; it was calculated as the minimum value of the square root of [(1 − sensitivity)2 + (1 − specificity)2], and greater accuracy is reflected by a smaller distance to point (0, 1) in the ROC curve.
cPPV: predictive positive value.
dPNV: predictive negative value.
eSignificant P values.