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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Cell Signal. 2014 Nov 15;27(2):257–266. doi: 10.1016/j.cellsig.2014.11.009

Fig. 2.

Fig. 2

The NR4A family and key signaling pathways regulate each other. Both the expression and function of the NR4A members are mediated by activation or inhibition of multiple signaling pathways. Growth factor signaling upregulates the expression and nuclear localization of NR4A members and inhibits NR4A nuclear export and cell death. Additionally, NR4A members can either positively regulate oncogenic signaling pathways (i.e. HIF, β-catenin, mTOR) or overcome tumor suppressor signaling (i.e., pVHL, p53, LKB1).