Table 1.

Summary of gene expression changes after treatment with NR4A agonists or antagonists.

Symbol	Gene name	Compound		Detection^a		NR4A-dependent?	Direct?	Cancer type	Ref
ATF3	Activating transcription factor 3	DIM-C-pPhOCH₃	Agonist	Increased	M,G	No	n.d.	Colon	141
ATF3	Activating transcription factor 3	DIM-C-pPhOCH₃	Agonist	Increased	M,G, P	Yes; Nur77	n.d.	Pancreatic	143
ATF4	Activating transcription factor 4	DIM-C-pPhOH	Antagonist	Increased	P	Yes; Nur77	n.d.	Pancreatic	12
BCL2	B-cell lymphoma 2	DIM-C-pPhOH	Antagonist	Decreased	P	n.d.^b	n.d.	Pancreatic, Lung	11, 76
BIRC5	Baculoviral IAP repeat containing 5 (Survivin)	DIM-C-pPhOH	Antagonist	Decreased	G, P, R, C	Yes; Nur77	Yes	Pancreatic, Lung	11, 76
BRE	Brain and reproductive organ-expressed	Cytosporone B	Agonist	Decreased	M, G, P, R, C	Yes; Nur77	Yes	Gastric
CDKN1A	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	DIM-C-pPhOCH₃	Agonist	Increased	M, G, P, R, C	Yes; Nur77	Yes	Pancreatic, Bladder	77, 142, 143
CDKN1A	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	DIM-C-Ph	Agonist	Increased	G	n.d.	n.d.	Pancreatic	142
DDIT3	DNA-damage-inducible transcript 3 (CHOP)	DIM-C-pPhOH	Antagonist	Increased	G, P	Yes; Nur77	n.d.	Pancreatic	12
MYC	V-Myc avian myelocytomatosis viral oncogene homolog (c-Myc)	DIM-C-pPhOH	Antagonist	Decreased	P	n.d.	n.d.	Lung	76
CTH	Cystathionase (cystathionine gamma-lyase)	DIM-C-pPhOCH₃	Agonist	Increased	M, G	No	n.d.	Colon	141
CTH	Cystathionase (cystathionine gamma-lyase)	DIM-C-pPhOCH₃	Agonist	Increased	M, G	Yes; Nur77	n.d.	Bladder, Pancreatic	77, 143
DUSP1	Dual specificity phosphatase 1	DIM-C-pPhOCH₃	Agonist	Increased	M, G	Yes; Nur77	n.d.	Pancreatic	143
EGFR	Epidermal growth factor receptor	DIM-C-pPhOH	Antagonist	Decreased	P	n.d.	n.d.	Lung	76
FASLG	Fas ligand (TNF superfamily, member 6)	DIM-C-pPhOCH₃	Agonist	Increased	P	Yes; Nur77	n.d.	Pancreatic	143
GDF15	Growth differentiation factor 15 (NAG-1)	DIM-C-pPhOCH₃	Agonist	Increased	M, G	No	n.d.	Bladder, Pancreatic	77, 143
PDCD1	Programmed cell death 1	DIM-C-pPhOCH₃	Agonist	Increased	M, G	Yes; Nur77	n.d.	Colon	141
NUPR1	Nuclear protein, transcriptional regulator 1 (p8)	DIM-C-pPhOCH₃	Agonist	Increased	M, G	Yes; Nur77	n.d.	Bladder	77
SESN2	Sestrin 2	DIM-C-pPhOCH₃	Agonist	Increased	M, G	Yes; Nur77	n.d.	Bladder	77
SESN2	Sestrin 2	DIM-C-pPhOH	Antagonist	Increased	G, P, R, C	Yes; Nur77	No	Lung	76
TNFSF10	Tumor necrosis factor (ligand) superfamily, member 10 (TRAIL)	DIM-C-pPhOCH₃	Agonist	Increased	G, P	Yes; Nur77	n.d.	Pancreatic, Colon, Bladder	77, 140, 141, 143
		DIM-C-pPhCH₃	Agonist	Increased	P	n.d.	n.d.	Pancreatic	140
		DIM-C-Ph	Agonist	Increased	G, P	n.d.	n.d.	Pancreatic, Colon, Bladder	77, 140, 141
		DIM-C-pPhCI	Agonist	Increased	G, P	Yes; Nurri	n.d.	Bladder	146
TXNDC5	Thioredoxin domain containing 5	DIM-C-pPhOH	Antagonist	Decreased	M, G, P, R, C	Yes; Nur77	Yes	Pancreatic	12
XBP1	X-box binding protein 1	DIM-C-pPhOH	Antagonist	Increased	P	Yes; Nur77	n.d.	Pancreatic	12

Detection key: M=microarray, G=gene, P=protein, R=promoter reporter, C=chromatin IP

not determined