Table 2.
Baseline Characteristics
| DASI Score Quartile | |||||
|---|---|---|---|---|---|
| Variable | <15.5 | 15.5–26.1 | 26.2–42.7 | >42.7 | p-value |
| Age [years] | 68 ± 11 | 69 ± 11 | 66 ± 11 | 64 ± 11 | <.0001 |
| Male (%) | 45.4 | 60.0 | 72.6 | 81.0 | <.0001 |
| BMI [kg/m2] | 29.8 [25.9, 35.1] | 28.4 [24.8, 33.3] | 28.1 [25.2, 32.3] | 28.9 [25.5, 32.3] | 0.001 |
| Diabetes Mellitus (%) | 49.3 | 44.4 | 35.8 | 27.2 | <.0001 |
| Hypertension (%) | 83.0 | 80.0 | 79.3 | 78.2 | 0.4 |
| Coronary Artery Disease (%) | 80.3 | 75.4 | 77.3 | 69.7 | 0.003 |
| Smoking History (%) | 66.6 | 72.1 | 74.3 | 75.2 | 0.03 |
| LVEF [%] | 45 [30, 55] | 40 [25, 55] | 40 [25, 55] | 40 [29, 55] | 0.4 |
| BNP [pg/ml] | 457 [155, 971] | 337 [136, 781] | 316 [119, 639] | 205 [86,411] | <.0001 |
| eGFR [mL/min/1.73 m2] | 56.1 [41.9, 74.0] | 57.1 [42.8, 74.1] | 59.0 [46.8, 75.0] | 61.7 [49.9, 76.0] | 0.001 |
| Beta-Blocker (%) | 66.8 | 68.0 | 68.0 | 65.2 | 0.8 |
| ACEI/ARB (%) | 63.9 | 67.7 | 68.8 | 70.5 | 0.2 |
| Loop Diuretic (%) | 68.1 | 69.3 | 55.2 | 40.7 | <.0001 |
*
Values are either mean +/− standard deviation or median [IQR] unless stated; p-values calculated via ANOVA or Kruskall-Wallis test for continuous variables and chi-square method for categorical variables.
**
Abbreviations: BMI: body mass index; DASI: Duke Activity Score Index; LVEF: left ventricular ejection fraction; BNP: brain natriuretic peptide; eGFR: estimated glomerular filtration rate, MDRD; ACEI: angiotensin converting enzyme inhibitor; and ARB: angiotensin receptor blocker.