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. Author manuscript; available in PMC: 2015 Dec 22.
Published in final edited form as: Dev Cell. 2014 Dec 4;31(6):747–760. doi: 10.1016/j.devcel.2014.10.024

Figure 6. Phorbol ester (PMA) gradients bypass the need for PDGF receptors and PLCγ, but not PKCα or Myosin II function.

Figure 6

A. Wind-rose plot of IA32 fibroblasts chemotaxing in PMA gradients (n=89).

B. Wind-rose plots show that PMA gradients rescue chemotaxis of both IA32 fibroblasts in a uniform concentration of PDGF-R inhibitor AG1296 (1 μM) (n=45) and that of PLCγ1 -/- fibroblasts (n=61).

C. Circular histograms showing no rescue of chemotaxis of PKCα KD (n=85) or mutant Myo-RLC(S1AS2A) cells (n=187) in PMA gradients.