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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Biochem Pharmacol. 2014 Nov 7;93(1):85–91. doi: 10.1016/j.bcp.2014.10.014

Figure 2.

Figure 2

Modulation of Gβγ subunit signaling by aripiprazole and reference DRD2 ligands in HEK-AC2/D2 cells. A. Activation of Gβγ signaling was assessed by measuring DRD2 potentiation of the AC2-stimulated cAMP accumulation in HEK-AC2/D2 cells. B. Antagonism of dopamine’s Gβγ response through the DRD2. Cells were treated with antagonists for 30 min, followed by a 1 h incubation with 300 nM dopamine in the presence of 1 µM PMA and 0.5 mM IBMX. Data shown represent the average and S.E.M. of at least three independent experiments conducted in duplicate.