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. Author manuscript; available in PMC: 2015 Nov 6.
Published in final edited form as: Cell Stem Cell. 2014 Oct 9;15(5):619–633. doi: 10.1016/j.stem.2014.09.009

Figure 1. BMP signaling is temporally regulated and required to maintain matrix TACs.

Figure 1

(A) pSMAD1/5 patterns throughout the hair cycle. (B) Early anagen HFSCs fail to downregulate pSMAD1/5 after Shh ablation. (C) Bmpr1a ablation leads to precocious HFSC activation. (D) Quantifications of changes in %Ki67+ hair bulb cells with time following Bmpr1a ablation in HFSCs. (E) Long term loss of BMP signaling leads to HF cysts composed largely of ORS (K17+), early matrix (LEF1+) and IRS-TACs (GATA3+). (F) Within a planar midsection of the hair bulb, more central cortical HS-TACs exhibit stronger nuclear pSMAD1/5 reactivity than more distal GATA3+ TACs. Cre-promoters are given in parentheses. Ana, anagen; Telo, telogen; Bu, bulge; HG, hair germ; DP, dermal papilla; Mx, matrix; Cx, cortex; IRS, inner root sheath. Data are represented as mean±SEM. *** = p<0.001 using Anova. Scale bars = 25 μm.