(A), (B) Immunoblotting analysis shows that CSNK1α1 is expressed in MM (MM lines, n=8; MM patient cells, n=5). (C) MM1S cells were treated with bortezomib at the concentrations indicated for 12h (left) or with 20nM bortezomib for time internal, as indicated (right). Whole cells lysates were analyzed with immunoblotting against ubiquitin, CSNK1α1, and GAPDH. GAPDH or Tubulin served as loading controls.