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Binding of RANKL to RANK initiates a sequence of signal transduction pathways mediated though TNF receptor-associated factor 6 (TRAF6), including NF-κB, c-JunN-terminal kinase (JNK)/cJun/fos and nuclear factor of activated T cells (NFAT) that initiate the differentiation of the early osteoclast precursor into a preosteoclast.
