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. 2014 Nov 5;289(52):35757–35769. doi: 10.1074/jbc.M114.595512

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — LPA₂-dependent cell migration was inhibited by a PLC-β inhibitor. A, frequency of LPA-induced Ca²⁺ puffs in DKO-LPA₂ MEFs treated with PLC-β inhibitor U73122 (2 μm) or its inactive analog U73343 (2 μm). B, kinetics of the relative wound density in the presence of U73122 (2 μm), U73343 (2 μm), or either U73122 or U73343 plus LPA (1 μm). The data were analyzed using IncuCyte^TM software. C, the migration of DKO-LPA₂ MEFs at the basal or LPA-activated state with U73122 (2 μm) or U73343 (2 μm) treatment. Error bars, S.E.