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. 2014 Nov 6;289(52):35806–35814. doi: 10.1074/jbc.M114.595397

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Sesn2 knockdown suppresses growth of xenografted A431 and A375 human tumors in nude mice. A, average volume (mm³) of A431-shNC and A431-shSesn2 tumors at different weeks after subcutaneous injection. B, representative tumors from xenografted A431 group. C, differences in tumor weight in xenografted A431 group. D and E, average volume (mm³) of A375-shNC and A375-shSesn2 (D); MEL624-shNC and MEL624-shSesn2 (E) tumors at different weeks after subcutaneous injection. F, MTS and BrdU assay of in vitro cell proliferation of A431, MEL624, and A375 cells infected with a lentiviral vector expressing shNC or shSesn2. G, immunoblot analysis of Sesn2, p-AKT, AKT, and GAPDH in xenografted A431 human tumors in nude mice. For all of the graphs, data are shown as the mean ± S.E. (n = 3). *, p < 0.05; t test, compared with the control group; all other comparisons were not significant.