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Structures showing interactions between the h1 + 1 residue of the BH3 domain on pro-survival proteins and the α1 helix. In Bcl-xL (PDB code 1PQ0) (A), Bcl-2 (PDB code 2XA0) (B), and Bcl-w (PDB code 1O0L) (C), the h1 + 1 residue makes hydrogen bond/salt bridges with residues on the α1 helix, whereas in Mcl-1 (PDB code 1WSX) (D), the h1 + 1 leucine makes hydrophobic contacts.
