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. 2014 Nov 4;289(52):36101–36115. doi: 10.1074/jbc.M114.598383

FIGURE 1.

FIGURE 1.

The induction of E-cadherin and the repression of N-cadherin, snail, and slug in shRNA-Ascl2/HT-29 cells or shRNA-Ascl2/LS174T cells and their tumor xenografts indicate the reversal of EMT. Ascl2 knockdown in HT-29 cells or LS174T cells increased the protein and mRNA levels of E-cadherin and reduced the protein and mRNA levels of N-cadherin, snail, and slug (A–C). The protein and/or mRNA levels in the tumor xenografts developed from shRNA-Ascl2/HT-29 cells or shRNA-Ascl2/LS174T cells displayed changes similar to those observed in the corresponding cells (D). β-Actin was used as a loading control (*, p < 0.05; **, p < 0.01). Error bars represent S.D.