Evaluation of the cataract prevalence rate and opacity score in the aging populations of Grx2 KO mice and age-matched WT mice.
A, prevalence rate of cataract in Grx2 KO mice (●) and WT mice (■). Side panel shows the number of opacity eyes over the total eyes in respective Grx2 KO and WT mice, corresponding to the ages of the animals. B, opacity score in WT and Grx2 KO mice. Opacity was quantified using the LOCS II system, and the sum of the scores was used to analyze the severity of the cataract. The same ophthalmologist gave the cataract scores without prior knowledge of the mouse genotype. *, p < 0.05 versus age-matched WT. C, slit lamp images of representative eyes. Lenses of Grx2 KO and age-matched WT mice ranging from 3 to 16 months (m) were examined. Eyes were dilated under nonanesthetized conditions.