Skip to main content
. 2014 Dec 17;7(12):1069–1090. doi: 10.3390/ph7121069

Figure 8.

Figure 8

GABAB receptors are not involved in KRS-5Me-4-OCF3-evoked inhibition. (A) Original recording from a mitral cell during KRS-5Me-4-OCF3 application in ACSF condition and in the presence of GABABR antagonist CGP55845 (10 μM). The upper trace (i) illustrates the effect of KRS-5Me-4-OCF3 on spiking of a mitral cell and the effect of adding CGP55845. The upper trace is shown at an extended time scale in the middle (ii) and lower trace (iii). (B) The normalized results showed the persistence of KRS-5Me-4-OCF3-evoked inhibitory effects on spiking of mitral cells in the presence of the GABAB receptor antagonist CGP55845 (10 µM) and the GABAB receptor agonist (R)-baclofen (50 µM) (* p < 0.05, *** p < 0.001). The data for the effect of KRS-5Me-4-OCF3 on spiking of mitral cells were normalized with respect to ACSF, or CGP88545 or baclofen alone. From [18].