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(A) Structure of the Nbr1-UBA domain in complex with Ub (PDB code 2MJ5), showing the UBA-interacting residues. (B) Putative model explaining the affinity of p62 or Nbr1 for Lys63-Ub2 chains. Upon binding via the PB1 domain, dimerization may favor the binding of the p62- or Nbr1-UBA domains to Lys63-Ub2. The structure of the Nbr1UBA/Ub complex has been superimposed on the structure of Lys-Ub2 (PDB code 2JF5).
