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. 2014 Nov 12;3(4):1027–1088. doi: 10.3390/cells3041027

Figure II.

Figure II

Structures of the Ataxin-3 Josephin/Ub (A) binary complexes, showing the two binding sites available on the Josephin domain. (B) Upon binding to polyUb chains, the Ataxin-3UIM12 domains adopt a compact structure (PDB code 2KLZ). (C) Structure of USP7/HAUSP (PDB code 1NBF) and CYLD (PDB code 2VHF) in complex with Ub. The positioning of Ub on CYLD arises from the structural alignment of USP7/HAUSP-Ub on CYLD. The absence of Fingers domain and an extended loop near the catalytic domain renders CYLD specific toward UbK63 chains and prevent UbK48 from binding.