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. 2014 Nov 25;6(4):2313–2329. doi: 10.3390/cancers6042313

Figure 5.

Figure 5

Blockade of HGF/Met-driven anchorage-independent growth by crizotinib and cabozantinib. Cells were plated in soft agar, followed by (A–C) 5 nM of crizotinib (PF1066) or (D–F) 30 nM of cabozantinib (XL184) treatment in the absence or the presence of HGF (1 nM) every other day. On day 7 colony growth was measured using MTT. Values represent the mean ± SD of triplicate samples and are representative of three experiments; asterisks (*) indicate significant differences from control (p < 0.05).