Table 2.
Xenografting of mammalian testis tissue from mature donors.
| O1 | F2 | SF3 | Donor species (Common name) |
Donor age4 |
Most advanced germ cell in donor tissue (Reason) |
Outcome | Time postgrafting5 |
Reference |
|---|---|---|---|---|---|---|---|---|
| RODENTIA | ||||||||
| CRICETIDAE | ||||||||
| Phodopus sungorus | Azospermia (Photoregressed) | Spermatocytes | 7 wk | Schlatt et al. 2002 | ||||
| (Djungarian hasmter) | ||||||||
| CARNIVORA | ||||||||
| CANIDAE | ||||||||
| Canis lupus familiaris | 7–22 mo | Sperm 5–80% | Degenerated | 16.8 wk | Abrishami et al. 2010a | |||
| (Domestic dog) | ||||||||
| FELIDAE | ||||||||
| Felis Catus | 8–15 mo | Sperm | Degenerated | 10 wk | Kim et al. 2007 | |||
| (Domestic cat) | ||||||||
| Lynx pardinus | 2 yr | Spermatogonia (Feline leukaemia) | Degenerated | 22 wk | Arregui et al. 2013 | |||
| (Iberian Lynx) | ||||||||
| PERISSODACTYLA | ||||||||
| EQUIDAE | ||||||||
| Equus ferus caballus | 2 yr | Round spermatids | Spermatocytes | 15 wk | Arregui et al. 2008b | |||
| (Domestic horse) | 1–4 yr | Sperm 38–69% | Spermatocytes | 16.8 wk | Rathi et al. 2006 | |||
| 1–4 yr | Spermatogonia (Cryptorchidism) | Spermatocytes | 16.8 wk | Turner et al. 2010 | ||||
| 5–25 yr | Sperm | Degenerated | 16.8 wk | |||||
| 9–28 yr | Azoospermia (ITD) | Degenerated | 29.4 wk | |||||
| Equus africanus | 13 mo | Sperm 33% | Sperm | 15.2 wk | Arregui et al. 2008b | |||
| (Domestic donkey) | ||||||||
| CETARTIODACTYLA | ||||||||
| SUIDAE | ||||||||
| Sus scrofa domesticus | 8–11 mo | Sperm 86–88% | Degenerated | 5 wk | Arregui et al. 2008b | |||
| (Domestic pig) | ||||||||
| BOVIDAE | ||||||||
| BOVINAE | ||||||||
| Bos taurus | 7 mo | Sperm 9% | Sertoli cells | 27 wk | Arregui et al. 2008b | |||
| (Domestic cattle) | 8 mo | Sperm | Spermatocytes | 11 wk | Huang et al. 2008 | |||
| 3 yr | Sperm 73% | Degenerated | 8 wk | Arregui et al. 2008b | ||||
| CAPRINAE | ||||||||
| Capra hircus | 1.5–4 yr | Sperm 75–87% | Degenerated | 9 wk | Arregui et al. 2008b | |||
| (Domestic goat) | ||||||||
| PRIMATES | ||||||||
| CERCOPITHECIDAE | ||||||||
| Macaca mulatta | 3 yr | Sperm 67% | Sperm | 21 wk | Arregui et al. 2008b | |||
| (Rhesus monkey) | 6 yr | Sperm 76% | Spermatocytes | 4 wk | ||||
| 11 yr | Sperm 86% | Sertoli cells | 3.8 wk | |||||
| 12 yr | Sperm 78% | Degenerated | 21 wk | |||||
| HOMINIDAE | ||||||||
| Homo sapiens | 32–40 yr | Sperm (Obstructive azoospermia) | Degenerated | 2–19 wk | Schlatt et al. 2006 | |||
| (Human being) | 32–40 yr | Azoospermia (Chemotherapy) | Sertoli cells only | 2–19 wk | ||||
| - | Spermatogonia (Horm. suppression) | Spermatogonia | 6–10 wk | |||||
| - | Sperm | Spermatogonia | 5–15 wk | Schlatt et al. 2006; Geens et al. 2006 | ||||
1
Order.
2
Family.
3
Subfamily.
4
Dy: days, wk: weeks, mo: months and ye: years.
*
Percentage refers to the percentage of seminiferous tubules presenting sperm,
5
Time has been expresed in weeks (wk) by dividing by 7 when it was given in days and multiplied by 4.2 when it was shown in months.