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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Immunol Rev. 2015 Jan;263(1):90–105. doi: 10.1111/imr.12245

Fig. 1. Bispecific antibodies.

Fig. 1

Bispecific antibodies were generated by genetic or chemical cross-linking of monoclonal antibodies (mAbs) or by F(ab’)2 fragments (upper row). Antibody engineering permitted the generation of small bispecific antibodies comprising the variable heavy (VH) and light (VL) domains of the original mAbs (lower row). Single-chain fragment variable (scFv); single-chain bi-specific tandem variable domain (BiTEs) and dock-and-lock trivalent Fab (DNL-(F(ab)3)). Modified figure from Stamova et al. (35).