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. 2014 Dec 17;9:127–146. doi: 10.2147/DDDT.S68501

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© 2015 He et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effect of SCE, SchA, and SchB on the expression of nuclear and total Nrf2 and Keap1. Human hepatocellular liver carcinoma cell line cells were treated with SCE at 100–300 µg/mL, 20 µM SchA, or 200 µM SchB for 24 hours. Whole cellular and nucleic lysates were subject to Western blotting analysis. (A) Representative blots of nuclear and total Nrf2 and Keap1 in human hepatocellular liver carcinoma cell line cells. (B–D) Bar graphs to show the relative expression level of nuclear and total Nrf2 (B and C) and Keap1 (D), respectively. Nicotinamide adenine dinucleotide phosphate was used as the internal control. Data are presented as the mean ± standard deviation (n=3).

Notes: *P<0.05; **P<0.01; and ***P<0.001 by one-way analysis of variance.

Abbreviations: SCE, Schisandra chinensis extract; Sch, schisandrin; Nrf2, nuclear factor (erythroid-derived 2)-like 2; Keap1, Kelch-like ECH-associated protein 1; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; Ctrl, control.