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. 2014 Dec 17;9:127–146. doi: 10.2147/DDDT.S68501

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© 2015 He et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Proposed underlying mechanism for the effect of SCE on drug metabolizing enzymes and drug transporters via Nrf2-mediated signaling pathway. Taken together, our findings have shown that pretreatment of human hepatocellular liver carcinoma cell line cells with SCE increased Nrf2 stability and half-life, mainly via downregulation of Keap1 and inhibition of Nrf2 degradation.

Abbreviations: SCE, Schisandra chinensis extract; Nrf2, nuclear factor (erythroid-derived 2)-like 2; Keap1, Kelch-like ECH-associated protein 1; ARE, antioxidant response element; NQO1, NAD(P)H:quinone oxidoreductase 1; HO-1, heme oxygenase-1; GSTA4, glutathione S-transferase A4; GCLM, glutamate–cysteine ligase, modifier subunit; GSTs, glutathione S-transferases; P-gp, P-glycoprotein; MRPs, multidrug resistance-associated proteins; OATP, organic anion transporting polypeptide.