Table 2. Associations at novel loci for incident CHD in African Americans: discovery and replication.
| Discovery | Replication | ||||||||||||
| African Americans* | African Americans† | European ancestry# | Discovery and replicationAfrican Americans | ||||||||||
| Nearby gene | SNP | Allele | MAF | Event/Total | HR (95% CI) | P | Event/Total | P | Event/Total | P | Beta (se) | P | Event/Total |
| MYC | rs2070583 | A/G | 0.02 | 546/8,201 | 2.47 (1.77, 3.44) | 8.1×10−8 | 577/8,059 | 0.30 | 2,405/24,024 | 0.79 | −0.6594 (0.1324) | 6.3×10−7 | 17,513 |
| MYC | rs4645948 | A/G | 0.02 | 546/8,198 | 2.46 (1.74, 3.48) | 3.8×10−7 | 577/8,059 | 0.48 | 2,405/24,024 | 0.77 | 0.6259 (0.1404) | 8.2×10−6 | 16,257 |
| ADRA1A | rs1965328 | A/G | 0.52 | 546/8,199 | 1.32 (1.17, 1.50) | 7.9×10−6 | 577/8,059 | 0.52 | 2,405/24,024 | 0.07 | 0.1166 (0.0437) | 7.7×10−3 | 16,258 |
CI, confidence interval; HR, hazard ratio; MAF, minor allele frequency; N, number; SNP, single nucleotide polymorphism. MAF for SNPs in HapMap CEU samples are: rs2070583 G allele = 0.009, rs4645948 T allele = 0.027 and rs1965328 A allele = 0.265.
P for between-study heterogeneity was not significant. SNPs were eligible for replication if P<1.0×10−5. The array wide significant threshold is P<2.8×10−7. Replication was considered a P<0.05 in replication samples and/or a P less than discovery in the combined discovery and replication samples. Note CHD events do not include procedures.
* Atherosclerosis Risk in Communities study and Women's Health Initiative study; † Additional samples from Women's Health Initiative, GeneSTAR and Health ABC studies; #CHARGE Consortium.