Table 1. Genes with ±1.3 or greater fold change after chronic ethanol treatment.
Symbol | Gene Name | Fold Change | Corrected p-value |
Aacs | Acetoacetyl-CoA synthetase | −2.4913 | 0.0090 |
Abcc4 | ATP-binding cassette, subfamily C (CFTR/MRP), member 4 | −1.7972 | 0.0287 |
Acat3 | Acetyl-Coenzyme A acetyltransferase 3 | −1.9462 | 0.0113 |
Acsm2 | Acyl-CoA synthetase medium-chain family member 2A | −1.7458 | 0.0311 |
Actg1 | Actin, gamma 1 | −1.3990 | 0.0106 |
Aldh1a7 | Aldehyde dehydrogenase family 1, subfamily A7 | −8.0352 | 0.0226 |
Ankrd44 | Ankyrin repeat domain 44 | 1.4922 | 0.0442 |
Apex1 | APEX nuclease (multifunctional DNA repair enzyme) 1 | −1.4432 | 0.0262 |
Arhgap29 | Rho GTPase activating protein 29 | 1.3020 | 0.0415 |
Arl5b | ADP-ribosylation factor-like 5B | 1.3029 | 0.0324 |
Basp1 | Brain abundant, membrane attached signal protein 1 | −1.6695 | 0.0131 |
Bckdk | Branched chain ketoacid dehydrogenase kinase | −1.3679 | 0.0056 |
Bcl3 | B-cell CLL/lymphoma 3 | −1.4100 | 0.0393 |
Cbs | Cystathionine beta synthase | −1.3411 | 0.0415 |
Creb3l1 | cAMP responsive element binding protein 3-like 1 | −1.3710 | 0.0324 |
Csad | Cysteine sulfinic acid decarboxylase | −2.3927 | 0.0463 |
Csmd1 | CUB and Sushi multiple domains 1 | −2.3761 | 0.0157 |
Cyp51 | Cytochrome P450, family 51 | −1.5255 | 0.0056 |
D3ZT51 | −1.4147 | 0.0415 | |
Dguok | Deoxyguanosine kinase | * | 0.0009 |
Dhcr24 | 24-dehydrocholesterol reductase | −1.3771 | 0.0391 |
Dhcr7 | 7-dehydrocholesterol reductase | −1.9364 | 0.0307 |
Dph1 | DPH1 homolog (S. cerevisiae) | −1.4021 | 0.0392 |
Efhc1 | EF-hand domain (C-terminal) containing 1 | # | 0.0055 |
Ephb1 | Eph receptor B1 | # | 0.0262 |
Fam73b | Family with sequence similarity 73, member B | −1.3103 | 0.0452 |
Fdft1 | Farnesyl diphosphate farnesyl transferase 1 | −1.5468 | 0.0105 |
Fdps | Farnesyl diphosphate synthase | −1.4441 | 0.0095 |
Gck | Glucokinase | −2.1995 | 0.0080 |
Gclc | Glutamate-cysteine ligase, catalytic subunit | −1.3119 | 0.0182 |
Gm6484 | Predicted gene 6484 | −1.8603 | 0.0195 |
Gpatch3 | G patch domain containing 3 | −1.3652 | 0.0476 |
Gsta3 | Glutathione S-transferase alpha 3 | −1.5341 | 0.0415 |
Hes6 | Hairy and enhancer of split 6 (Drosophila) | −1.5687 | 0.0416 |
Hip1r | Huntingtin interacting protein 1 related | −1.3085 | 0.0080 |
Hmgcr | 3-hydroxy-3-methylglutaryl-CoA reductase | −1.6268 | 0.0324 |
Hmgcs1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | −2.0623 | 0.0064 |
Hsd17b7 | Hydroxysteroid (17-beta) dehydrogenase 7 | −1.5221 | 0.0480 |
Idi1 | Isopentenyl-diphosphate delta isomerase 1 | −2.0524 | 0.0056 |
Irs2 | Insulin receptor substrate 2 | 1.6998 | 0.0415 |
Itgal | Integrin, alpha L | 1.3163 | 0.0339 |
Kif26b | Kinesin family member 26B | −3.0480 | 0.0350 |
Klf9 | Kruppel-like factor 9 | 1.4918 | 0.0195 |
LOC100359951 | −1.3843 | 0.0415 | |
LOC100361376 | −1.4853 | 0.0389 | |
LOC494499 | −1.5858 | 0.0441 | |
LOC682888 | −1.4953 | 0.0172 | |
Lss | Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | −1.5008 | 0.0022 |
Me1 | Malic enzyme 1, NADP(+)-dependent, cytosolic | −1.7325 | 0.0308 |
Mid1ip1 | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | −1.5504 | 0.0262 |
Mrps18b | Mitochondrial ribosomal protein S18B | −1.3708 | 0.0262 |
Mrps2 | Mitochondrial ribosomal protein S2 | −1.3651 | 0.0009 |
Mrps34 | Mitochondrial ribosomal protein S34 | −1.3264 | 0.0365 |
Mvd | Mevalonate (diphospho) decarboxylase | −2.0150 | 0.0195 |
Nabp1 | Oligonucleotide/oligosaccharide-binding fold containing 2A | −1.3573 | 0.0255 |
Ndufaf4 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 | −1.3623 | 0.0106 |
Oat | Ornithine aminotransferase | 1.3563 | 0.0324 |
Olr1587 | Olfactory receptor 1587 | 7.9442 | 0.0415 |
Pam | Peptidylglycine alpha-amidating monooxygenase | 1.3639 | 0.0324 |
Pck1 | Phosphoenolpyruvate carboxykinase 1 (soluble) | 1.7312 | 0.0090 |
Pcsk9 | Proprotein convertase subtilisin/kexin type 9 | −1.3723 | 0.0324 |
Pinx1 | PIN2/TERF1 interacting, telomerase inhibitor 1 | −1.4089 | 0.0375 |
Pir | Pirin (iron-binding nuclear protein) | −1.9381 | 0.0370 |
Ppp1r3b | Protein phosphatase 1, regulatory subunit 3B | −1.3082 | 0.0195 |
Psat1 | Phosphoserine aminotransferase 1 | −1.7933 | 0.0450 |
Psme3 | Proteasome (prosome, macropain) activator subunit 3 | 1.6157 | 0.0171 |
Ptcd2 | Pentatricopeptide repeat domain 2 | −1.3706 | 0.0056 |
Ptpre | Protein tyrosine phosphatase, receptor type, E | * | 0.0056 |
Rrm2 | Ribonucleotide reductase M2 | 2.4855 | 0.0434 |
Sc4mol | Methylsterol monooxygenase 1 | −1.9263 | 0.0056 |
Scly | Selenocysteine lyase | −1.3971 | 0.0113 |
Scn1b | Sodium channel, voltage-gated, type I, beta | −1.4340 | 0.0056 |
Sds | Serine dehydratase | 2.4717 | 0.0441 |
Sds | Serine dehydratase | 4.7055 | 0.0114 |
Sema3d | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | * | 0.0044 |
Sert1 (AF077195) | Sertoli cell protein 1 | −10.2588 | 0.0415 |
Sfrs2 | Serine/arginine-rich splicing factor 2 | −1.3264 | 0.0169 |
Sfrs3 | Serine/arginine-rich splicing factor 3 | −1.4130 | 0.0072 |
Sqle | Squalene epoxidase | −2.1774 | 0.0056 |
Srebf1 | Sterol regulatory element binding transcription factor 1 | −1.5895 | 0.0420 |
Tcp11l2 | T-complex 11 (mouse) like 2 | 1.3396 | 0.0499 |
Tlr13 | Toll-like receptor 13 | 1.6008 | 0.0480 |
Tmem97 | Transmembrane protein 97 | −1.4464 | 0.0142 |
Tsku | Tsukushi | −2.1529 | 0.0182 |
Tuba1c | Tubulin, alpha 1C | −1.3522 | 0.0476 |
Tuba4a | Tubulin, alpha 4A | −1.6102 | 0.0098 |
Tubb2a | Tubulin, beta 2A class IIa | −1.6534 | 0.0113 |
Tubb4b | Tubulin, beta 4B class IVb | −1.3448 | 0.0216 |
Upp2 | Uridine phosphorylase 2 | 15.3404 | 0.0202 |
Wdr18 | WD repeat domain 18 | −1.3181 | 0.0182 |
Yars | Tyrosyl-tRNA synthetase | −1.4044 | 0.0098 |
Zbtb43 | Zinc finger and BTB domain containing 43 | 1.3794 | 0.0337 |
Zfand2a | Zinc finger, AN1-type domain 2A | −1.3342 | 0.0407 |
Zmynd19 | Zinc finger, MYND-type containing 19 | −1.3301 | 0.0339 |
* - Gene was solely expressed in water control. # - Gene was solely expressed in ethanol treatment.