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. 2014 Dec 26;9(12):e110501. doi: 10.1371/journal.pone.0110501

Table 1. Genes with ±1.3 or greater fold change after chronic ethanol treatment.

Symbol Gene Name Fold Change Corrected p-value
Aacs Acetoacetyl-CoA synthetase −2.4913 0.0090
Abcc4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 −1.7972 0.0287
Acat3 Acetyl-Coenzyme A acetyltransferase 3 −1.9462 0.0113
Acsm2 Acyl-CoA synthetase medium-chain family member 2A −1.7458 0.0311
Actg1 Actin, gamma 1 −1.3990 0.0106
Aldh1a7 Aldehyde dehydrogenase family 1, subfamily A7 −8.0352 0.0226
Ankrd44 Ankyrin repeat domain 44 1.4922 0.0442
Apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 −1.4432 0.0262
Arhgap29 Rho GTPase activating protein 29 1.3020 0.0415
Arl5b ADP-ribosylation factor-like 5B 1.3029 0.0324
Basp1 Brain abundant, membrane attached signal protein 1 −1.6695 0.0131
Bckdk Branched chain ketoacid dehydrogenase kinase −1.3679 0.0056
Bcl3 B-cell CLL/lymphoma 3 −1.4100 0.0393
Cbs Cystathionine beta synthase −1.3411 0.0415
Creb3l1 cAMP responsive element binding protein 3-like 1 −1.3710 0.0324
Csad Cysteine sulfinic acid decarboxylase −2.3927 0.0463
Csmd1 CUB and Sushi multiple domains 1 −2.3761 0.0157
Cyp51 Cytochrome P450, family 51 −1.5255 0.0056
D3ZT51 −1.4147 0.0415
Dguok Deoxyguanosine kinase * 0.0009
Dhcr24 24-dehydrocholesterol reductase −1.3771 0.0391
Dhcr7 7-dehydrocholesterol reductase −1.9364 0.0307
Dph1 DPH1 homolog (S. cerevisiae) −1.4021 0.0392
Efhc1 EF-hand domain (C-terminal) containing 1 # 0.0055
Ephb1 Eph receptor B1 # 0.0262
Fam73b Family with sequence similarity 73, member B −1.3103 0.0452
Fdft1 Farnesyl diphosphate farnesyl transferase 1 −1.5468 0.0105
Fdps Farnesyl diphosphate synthase −1.4441 0.0095
Gck Glucokinase −2.1995 0.0080
Gclc Glutamate-cysteine ligase, catalytic subunit −1.3119 0.0182
Gm6484 Predicted gene 6484 −1.8603 0.0195
Gpatch3 G patch domain containing 3 −1.3652 0.0476
Gsta3 Glutathione S-transferase alpha 3 −1.5341 0.0415
Hes6 Hairy and enhancer of split 6 (Drosophila) −1.5687 0.0416
Hip1r Huntingtin interacting protein 1 related −1.3085 0.0080
Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase −1.6268 0.0324
Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) −2.0623 0.0064
Hsd17b7 Hydroxysteroid (17-beta) dehydrogenase 7 −1.5221 0.0480
Idi1 Isopentenyl-diphosphate delta isomerase 1 −2.0524 0.0056
Irs2 Insulin receptor substrate 2 1.6998 0.0415
Itgal Integrin, alpha L 1.3163 0.0339
Kif26b Kinesin family member 26B −3.0480 0.0350
Klf9 Kruppel-like factor 9 1.4918 0.0195
LOC100359951 −1.3843 0.0415
LOC100361376 −1.4853 0.0389
LOC494499 −1.5858 0.0441
LOC682888 −1.4953 0.0172
Lss Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) −1.5008 0.0022
Me1 Malic enzyme 1, NADP(+)-dependent, cytosolic −1.7325 0.0308
Mid1ip1 MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) −1.5504 0.0262
Mrps18b Mitochondrial ribosomal protein S18B −1.3708 0.0262
Mrps2 Mitochondrial ribosomal protein S2 −1.3651 0.0009
Mrps34 Mitochondrial ribosomal protein S34 −1.3264 0.0365
Mvd Mevalonate (diphospho) decarboxylase −2.0150 0.0195
Nabp1 Oligonucleotide/oligosaccharide-binding fold containing 2A −1.3573 0.0255
Ndufaf4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 −1.3623 0.0106
Oat Ornithine aminotransferase 1.3563 0.0324
Olr1587 Olfactory receptor 1587 7.9442 0.0415
Pam Peptidylglycine alpha-amidating monooxygenase 1.3639 0.0324
Pck1 Phosphoenolpyruvate carboxykinase 1 (soluble) 1.7312 0.0090
Pcsk9 Proprotein convertase subtilisin/kexin type 9 −1.3723 0.0324
Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 −1.4089 0.0375
Pir Pirin (iron-binding nuclear protein) −1.9381 0.0370
Ppp1r3b Protein phosphatase 1, regulatory subunit 3B −1.3082 0.0195
Psat1 Phosphoserine aminotransferase 1 −1.7933 0.0450
Psme3 Proteasome (prosome, macropain) activator subunit 3 1.6157 0.0171
Ptcd2 Pentatricopeptide repeat domain 2 −1.3706 0.0056
Ptpre Protein tyrosine phosphatase, receptor type, E * 0.0056
Rrm2 Ribonucleotide reductase M2 2.4855 0.0434
Sc4mol Methylsterol monooxygenase 1 −1.9263 0.0056
Scly Selenocysteine lyase −1.3971 0.0113
Scn1b Sodium channel, voltage-gated, type I, beta −1.4340 0.0056
Sds Serine dehydratase 2.4717 0.0441
Sds Serine dehydratase 4.7055 0.0114
Sema3d Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D * 0.0044
Sert1 (AF077195) Sertoli cell protein 1 −10.2588 0.0415
Sfrs2 Serine/arginine-rich splicing factor 2 −1.3264 0.0169
Sfrs3 Serine/arginine-rich splicing factor 3 −1.4130 0.0072
Sqle Squalene epoxidase −2.1774 0.0056
Srebf1 Sterol regulatory element binding transcription factor 1 −1.5895 0.0420
Tcp11l2 T-complex 11 (mouse) like 2 1.3396 0.0499
Tlr13 Toll-like receptor 13 1.6008 0.0480
Tmem97 Transmembrane protein 97 −1.4464 0.0142
Tsku Tsukushi −2.1529 0.0182
Tuba1c Tubulin, alpha 1C −1.3522 0.0476
Tuba4a Tubulin, alpha 4A −1.6102 0.0098
Tubb2a Tubulin, beta 2A class IIa −1.6534 0.0113
Tubb4b Tubulin, beta 4B class IVb −1.3448 0.0216
Upp2 Uridine phosphorylase 2 15.3404 0.0202
Wdr18 WD repeat domain 18 −1.3181 0.0182
Yars Tyrosyl-tRNA synthetase −1.4044 0.0098
Zbtb43 Zinc finger and BTB domain containing 43 1.3794 0.0337
Zfand2a Zinc finger, AN1-type domain 2A −1.3342 0.0407
Zmynd19 Zinc finger, MYND-type containing 19 −1.3301 0.0339

* - Gene was solely expressed in water control. # - Gene was solely expressed in ethanol treatment.