Table 1. Summary of clinical signs in dogs following infestation with Rickettsia rickettsii–infected Dermacentor variabilis ticks; (Days post-infestation).

Dog (age)	Tick life stage	Fever above 39.5°C	Depression	Lethargy	Decreased appetite	Tremors	Petechiae on ocular mucosa	Petechiae on oral mucosa	Skin rash	PCR +
181 (4 mo.)	Larvae	5–11	5–17	9–11	6–11	8–11	8–17	7–11	7–13	5–13
424b (4 mo.)	Nymphs	3–11	5–17	none	6–17	6–15	6–17	11–13	6–15	7–13
362a (9 mo.)	Adults	5–8	7–14a	8–14a	8–14a	7–8, 13–14a	11–14a	11–14a	8–11	6–8
664b (9 mo.)	Adults	7–9	7–14	8–13	8–11, 14–15	7–14	8–18	8–17	8–17	8

^aDog 362 was euthanized at 14 DPI.

^bDogs 424 and 664 were treated with doxycycline starting 14 DPI.