Table 4.
Estimates of fitness and mutational parameters from the fitness assays
| Fitness (95% CI) | ΔM (× 10−3) per generation1 (95% CI [× 10−3 ]) | U 2 (SE) | E(a)3 (SE) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Strain | First Anc | First MA | Second Anc | Second MA | First | Second | First | Second | First | Second |
| CC-1952 | 0.153 (0.127, 0.178) | 0.100 (0.079, 0.121) | 0.130 (0.102, 0.158) | 0.108 (0.071, 0.145) | −0.051 (−0.071, −0.030) | −0.019 (−0.037, −0.001) | 3.80×10−3 (5.84×10−3) | 6.84×10−4 (1.03×10−3) | −1.34×10−2 (1.30×10−2) | −2.75×10−2 (2.67×10−2) |
| CC-2342 | 0.153 (0.138, 0.168) | 0.112 (0.061, 0.163) | 0.130 (0.112, 0.148) | 0.099 (0.078, 0.120) | −0.042 (−0.067, −0.017) | −0.017 (−0.035, +0.001) | 1.24×10−3 (1.87×10−3) | 3.92×10−4 (5.93×10−4) | −3.38×10−2 (3.28×10−2) | −4.27×10−2 (4.14×10−2) |
| CC-2344 | 0.107 (0.089, 0.125) | 0.092 (0.062, 0.121) | 0.114 (0.100, 0.128) | 0.105 (0.086, 0.124) | −0.016 (−0.036, +0.005) | −0.011 (−0.031, +0.008) | 3.68×10−4 (5.56×10−4) | 1.13×10−3 (1.71×10−3) | −4.27×10−2 (4.12×10−2) | −1.02×10−2 (9.89×10−3) |
| CC-2931 | 0.166 (0.145, 0.187) | 0.129 (0.110, 0.148) | 0.130 (0.111, 0.149) | 0.106 (0.088, 0.124) | −0.036 (−0.056, −0.015) | −0.017 (−0.034 +0.001) | 1.22×10−2 (1.84×10−2) | 4.89×10−4 (7.39×10−4) | −2.91×10−3 (2.82×10−3) | −3.39×10−2 (3.29×10 −2) |
| CC-2937 | − | − | 0.109 (0.098, 0.121) | 0.104 (0.090, 0.118) | − | −0.003 (−0.022, +0.016) | − | 3.13×10−5 (4.73×10−5) | − | −1.00×10−1 (9.70×10−2) |
Separate columns show estimates from the first and second replicate assays.
1Change in mean fitness per generation between the ancestral pseudolines (Anc) and MA lines (MA) for each strain.
2Bateman–Mukai estimates of the genomic deleterious mutation rate per generation.
3Bateman–Mukai estimates of the mean mutational effect per generation.