Table 2. Beta-cell function and insulin sensitivity parameters.
| Noncarriers | Carriers | P-value | |
| Baseline HOMA index (all) | |||
| HOMA-ir | 1.23[0.80–1.80] | 0.95[0.56–1.47] | 0.16 |
| HOMA-β | 79[48–128] | 78[49–147] | 0.89 |
| Insulinogenic index (ogtt) | 50.7[37.8–176.5] | 60.3[31.1–71.4] | 1.00 |
| (pmol/mmol) | |||
| AUCinsulin/AUCglucose ratio | 87.8[73.6–261.4] | 79.8[50.6–105.2] | 1.00 |
| (ogtt) (pmol/mmol) | |||
| ISIcomp (ogtt) | 23.9[20.9–41.5] | 33.5[18.5–46.9] | 0.07 |
| (µmol/(kg min pmol L)) | |||
| Disposition index (clamp) | 22.1[15.2–41.9] | 25.6[10.0–33.1] | 1.00 |
| MCR (ogtt) (ml/(min kg)) | 9.8[9.1–10.4] | 10.1[9.2–10.6] | 0.37 |
Values are presented as median [interquartile range]. Abbreviations: HOMA = homeostatis model assessment; AUC = area under the curve; ISIcomp = index of composite whole-body insulin sensitivity; MCR = metabolic clearance rate.