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. 2014 Dec 26;9(12):e115242. doi: 10.1371/journal.pone.0115242

Figure 5. NAC reduces oxidative injury.

Figure 5

To determine the mechanism behind distal organ injury, mice were pretreated intraperitoneally with, N-acetyl-cysteine (NAC). A, Compared to mice given vehicle control (No-NAC), NAC treated mice had significantly lower plasma I-FABP after 2 h of intestinal ischemia. B, NAC also affected defensins at 1 h ischemia, though no significance was achieved. C, MPO activity of lung homogenates illustrated a significant reduction in mice that were treated with NAC compared to vehicle controls (No-NAC) at 1 h ischemia. D, There was also significant reduction in TNF-α cytokine in lung homogenates after NAC treatment at 1 h ischemia. E, At 2 h ischemia, there was slight reduction in IL-1β in the NAC treated mice compared to vehicle controls, though significance was not achieved probably due to the short half-life of NAC. (n = 3 for shams, n = 4 for both No-NAC and NAC) # p<0.05 compared to vehicle (No-NAC) treated mice.