Table 1. Effect of Geld on P4-induced motility parameters in human sperm.

	No P4		2.5 µM P4
	Vehicle control	2.00 µM Geld	Vehicle control	2.00 µM Geld
VSL (µM/s)	56.9±2.3	49.5±3.5	62.4±2.6	45.2±3.5*
VCL (µM/s)	111.1±4.3	98.2±3.2	123.8±14.2	94.4±3.5
VAP (µM/s)	65.7±2.1	58.6±2.6	71.6±3.8	53.6±3.5*
STR (%)	83.5±1.0	82.3±2.2	84.3±0.9	61.0±1.2*
LIN (%)	50.0±1.6	49.7±1.8	50.3±3.7	46.7±1.5
ALH (µM)	5.2±0.2	5.1±0.3	5.7±0.8	5.1±0.1
BCF (Hz)	28.0±0.8	26.7±1.3	28.1±0.5	20.6±0.9 *
Progressive sperm (%)	41.3±3.4	38.7±±1.4	45.3 ± 1.7	31.0±7.9
Motility (%)	76.5±5.3	77.7±5.0	79.0±4.2	66.0±6.8*

Results are expressed as means ± standard error of the mean (SEM; n  =  6). In the presence of 2.5 µM progesterone (P4), geldanamycin (Geld) treatment significantly inhibited sperm motility, *P<0.05, 2.00 µM Geld vs. vehicle control. In the absence of P4, no difference between groups was observed. VSL, straight line velocity; VCL, curvilinear velocity; VAP, average path velocity; STR, straightness (VSL/VAP multiplied by 100); LIN, linearity (VSL/VCL multiplied by 100); ALH, amplitude of lateral head displacement; and BCF, beat-cross frequency.