Table 2. Genotype frequency, distribution, and genotype-specific mean age at death of the SNPs associated with lifespan.

Gene	Chromosome	rs#	Position	Genotype	Genotype frequency	Age at death	q-value	Partial correlation*
SIRT3	11p15.5	rs511744	209089	CC	591	87.2	0.046	0.0053
				CT	494	88.0
				TT	106	88.5
				Missing	1
SIRT5	6p23	rs2841505	13679574	TT	534	88.1	0.043	0.0053
				TG	539	87.3
				GG	119	86.8
				Missing
SIRT6	19p13.3	rs107251	4127085	CC	940	87.6	0.012	0.0075
				CT	239	88.0
				TT	10	82.1
				Missing	3
SOD3	4p15.2	rs2536512	24801315	GG	483	88.9	0.048	0.0057
				GA	466	87.8
				AA	124	87.4
				Missing	119
FOXO3	6q21	rs4946935	109000742	GG	540	87.3	0.042	0.0058
				GA	469	87.7
				AA	111	88.9
				Missing	72

*The partial correlation is a measure of the strength of the relationship between the SNP and mean age at death after controlling for gender, comorbidity count, smoking, alcohol consumption, BMI and the BMI × smoking interaction effect.

Of the 45 SNPs where the SNP × gender interaction effect was not significant, SIRT3, 5, 6, FOXO3 and SOD3 SNPs were associated with age at death. All SNPs gene, rs number, chromosome, chromosome position, genotype frequency, age at death, q-value and partial correlation are given.