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. 2014 Dec 26;9(12):e115848. doi: 10.1371/journal.pone.0115848

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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HPLC was used to measure serum A) Kynurenine and B) Tryptophan from Crohn's disease patients with moderate or severely active Crohn's disease. Controls, CD patients who did not carry SNPs of IDO1 (n = 20), were compared to CD patients who did carry IDO1 SNPs (n = 8). C) The Kyn/Trp ratio, a surrogate of IDO1 activity, was significantly lower in the patients with IDO1 SNPs.