Figure 1. Expression of Ror2 promotes in vivo tumor growth and invasion.

A&C) Tabulated rates of successful injection and growth of all 786-0 xenograft tumors are shown. B) Average tumor size (cm) with error bars showing stdev for resulting xenograft tumors following paired orthotropic injections of 786-0 cells containing either the control empty vector, pcDNA6 or hRor2 exhibited a trend to increased in vivo tumor growth with Ror2 overexpression. D) Average tumor size (mm) with error bars showing stdev for resulting xenograft tumors following subcutaneous injection of 786-0 cells containing either the control empty vector, GFP, wild-type Ror2, or Ror2-DM showed a significant increase in in vivo tumor growth with wild-type Ror2 overexpression. P-values were calculated using an Anova one-way analysis (*<.05 **<.01). E) Representative image of an orthotopic xenograft consisting of 786-0 vector control cells. F) Increased invasion of local tissues was evident with Ror2 expression, with arrows highlighting areas of continued invasion into the spleen.