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. 2014 Dec 26;9(12):e116064. doi: 10.1371/journal.pone.0116064

Figure 2. Growth and invasion of MMMT1, EEC2 and EEC4.

Figure 2

A) Primary tissues from malignant mixed mullerian tumor (MMMT1), were transplanted under the renal capsule of NSG mice that were OVX with or without E2. At 6 to 8 weeks after transplant, tumor was harvested and re-grafted into other mice (1–2 pieces/kidney). At P2, invasion of MMMT1 tissues to pancreas is shown. B) Primary tissues from endometrioid adenocarcinoma (EEC2), were transplanted under the renal capsule of OVX mice with E2. At 6 to 8 weeks after transplant, tumor was harvested and re-grafted into other mice (1–2 pieces/kidney). At P4, tissues were transplanted in OVX mice without E2 pellet. At P1, invasion of EEC2 tissues to the uterus is shown. C) Primary tissues from endometrioid adenocarcinoma (EEC4), were transplanted under the renal capsule of OVX mice with or without E2. At 6 to 8 weeks after transplant, tumor was harvested and re-grafted into other mice (1–2 pieces/kidney). At P3, invasion of EEC4 tissues to uterus is shown. Left panels show H&E stainings of primary tissues. Middle panels show passaged tissue grafts and H&E stainings. Right panels show invasion of tissue grafts and its H&E stainings. T, Tumor; K, Kidney; S, Spleen; P, Pancreas; Peri, Peritoneum; U, Uterus; V, Vagina. Scale bar; 200 um.