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. 2014 Dec 26;9(12):e115910. doi: 10.1371/journal.pone.0115910

Table 1. Clinical characteristics and electrocardiographic data.

CA with preserved EF Survivors Non-survivors P value
n = 41 n = 22 n = 19
Age (years) 65±9 65±8 65±11 0.825
Male (n; %) 61% 59% 63% 0.790
BMI (kg/m2) 24±3 23±2 24±4 0.355
Systolic blood pressure (mmHg) 119±19 122±17 116±21 0.354
Diastolic blood pressure (mmHg) 72±13 75±12 69±14 0.203
Heart rate (beats/min) 76±9 75±12 77±9 0.419
NYHA class 2.3±0.8 2.1±0.8 2.4±0.8 0.195
NYHA class III/IV, n (%) 44 33% 55% 0.162
Pleural effusion (%) 43% 37% 50% 0.419
Number of non-cardiac organs involved 1.5±0.9 1.2±0.8 1.8±0.8 0.017
Renal (%) 59% 45% 74% 0.069
Hepatic/gastrointestinal (%) 69% 65% 74% 0.557
Lung (%) 8% 0% 16% 0.106
Neuropathic (%) 5% 5% 5% 1.000
Soft tissues/bone (%) 10% 5% 16% 0.342
Biomarkers
NT-proBNP (pg/mL) 3813 (1546–14564) 1830 (998–21882) 4543 (2846–15193) 0.352
Creatinine (mg/mL) 1.2 (0.8–1.8) 1.1 (0.7–1.9) 1.2 (0.9–1.8) 0.845
GGT (UL) 91 (32–221) 74 (36–226) 111 (29–242) 0.684
AKP (UL) 83 (67–141) 73 (62–95) 90 (68–216) 0.125
Albumin (g/dL) 3.7 (3.0–4.1) 3.7(3.4–4.0) 3.6 (2.8–4.3) 0.756
Free Kappa light chain (mg/L) 21 (6–114) 21 (17–129) 16 (1.5–114) 0.384
Free Lambda light chain (mg/L) 22 (10–122) 12 (9–122) 31 (21–327) 0.082
Kappa/Lambda ratio 1.11 (0.07–8.40) 1.43 (0.327–12.70) 0.45 (0.01–7.84) 0.343
Cardiac-related drug therapy
Beta blocker 43% 50% 35% 0.368
Angiotensin converting enzyme inhibitor 38% 45% 29% 0.330
Diuretics 62% 50% 77% 0.098
Electrocardiography
Unexplained low voltage 50% 50% 50% 1.000
QRS-T wave pseudo-infarct changes 44% 45% 42% 0.855
I/II° atrioventricular block 64% 53% 75% 0.188
Left/right bundle branch block 39% 50% 26% 0.129

Non-survivors vs. survivors P<0.05 indicated significantly different. CA: cardiac amyloidosis; BMI: body mass index; NYHA class: New York Heart Association functional classification; NT-proBNP: N-terminal pro-B-type natriuretic peptide; GGT: Gamma-glutamyl transpeptidase; AKP: alkaline phosphatase enzyme.