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. 2014 Dec 26;9(12):e116165. doi: 10.1371/journal.pone.0116165

Figure 8. The NO-ULK1-SIRT1 pathway might be operative in the whole animal.

Figure 8

(A) Western blots of lung tissues of wild-type (C57BL/6J) and eNOS knock-out mice; (B) Western blots of lung tissues of wild-type (C57BL/6J) and db/db mice; (C) Western blots of lung tissues of wild-type (C57BL/6J) and db/db mice; (D) The proposed mechanism of the eNOS-derived NO regulation of SIRT1 protein turnover, which requires ULK1 and OGT, in vascular endothelial cells. *represents p<0.05 vs WT (n = 3 in eNOS-KO model; n = 5 in db/db model). WT, wild-type; eNOS, endothelial nitric oxide synthase; OGT, O-GlcNAc transferase.