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. 2014 Dec 23;2:e688. doi: 10.7717/peerj.688

Figure 2. Two representative processes of extravasation in cancer cells.

Figure 2

(A) Cancer cell invasion-type and endothelial covering-type extravasation in RFP-HeLa cells. Right panels show schematic outlines of the embolus-forming RFP-HeLa cells (red) and the surrounding endothelial cells (green). The numbers indicate the elapsed time in minutes. Bars, 40 µm. (B) The incidence of the 2 processes of extravasation. Seven larvae in which RFP-HeLa cells formed severe emboli were observed. Seventeen extravasation events were counted during the 11-h observations. (C) Side view of 3D reconstructed images. Some endothelial cells were extending over or penetrating through the embolus-forming RFP-HeLa cells (white arrows). Dashed lines in 2D image indicate locations of slicing along a vertical axis.