Serum ALT, AST, glucose and insulin levels in OLETF and OLET untreated rats and rats treated with ethanol. All data are mean ± SD of 10 rats in each group. (A) Serum ALT levels. *P < 0.001, OLETF untreated versus OLET untreated rats; *P < 0.001, OLETF rats versus OLET rats, ethanol for 5 d/wk; P < 0.01, OLETF rats ethanol 5 d/wk versus OLETF control rats. (B) Serum AST levels. P < 0.01, OLETF rats, ethanol 5 d/wk versus OLETF control rats. (C) Serum glucose levels. *P = 0.0005, OLETF control versus OLET control rats. Glucose levels were significantly higher in OLETF rats treated with ethanol for 5, 3 and 2 d/wk versus OLETF control rats. (D) Serum insulin levels. *P = 0.0005, OLETF control versus OLET control rats. Serum insulin levels were not altered significantly in any groups of OLETF rats treated with ethanol compared with OLETF control rats. (E) Serum adiponectin levels. *P < 0.001, OLETF control versus OLET control rats. P < 0.01 and P < 0.05, OLETF 5 d/wk and OLETF 3 d/wk versus OLETF control rats. Serum adiponectin levels did not alter in any groups of ethanol-treated OLET rats compared with untreated controls.