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. Author manuscript; available in PMC: 2014 Dec 27.
Published in final edited form as: J Viral Hepat. 2010 Jul 5;18(8):549–561. doi: 10.1111/j.1365-2893.2010.01335.x

Figure 1.

Figure 1

Figure 1

Longitudinal analysis of the magnitude (A-B) and breadth (C-D) of HCV-specific IFN-γ and IL-2 responses in clearers (n=12, white bars) and persisters (n=8, hatched bars) from baseline to week 48. A) A significantly higher magnitude of IFN-γ production was detected in clearers compared to persisters at baseline (p<0.001) and week 12 (p=0.019) by Mann-Whitney. B) Clearers maintained their HCV-specific IL-2 response with higher magnitude of IL-2 production compared to persisters screening to week 48. C) Clearers of HCV infection had significantly broader HCV-specific IFN-γ responses compared to persisters at baseline (p=0.004, Mann-Whitney) and week 12 (p=0.007, Mann-Whitney), and maintained a boarder response to week 48. D) Clearers demonstrated a trend of a broader IL-2 response baseline to week 48 compared to persisters. The horizontal solid lines in the box and whisker plots represent the median response. Four asterisks represent p<0.001, two asterisks represent p<0.01 and one asterisk represents p<0.05.