Table 1.
Preliminary screening of anticonvulsant activity in mice (i.p.).
| Compounds | R 1 | R 2 |
MES(mg/Kg)
a
,
b
|
||
|---|---|---|---|---|---|
| 200 | 100 | 30 | |||
| 5a | n-C6H13 | n-C2H5 | 0/3 | 0/3 | 0/3 |
| 5b | n-C6H13 | n-C3H7 | 0/3 | 0/3 | 0/3 |
| 5c | n-C6H13 | n-C4H9 | 0/3 | 0/3 | 0/3 |
| 5d | n-C6H13 | n-C5H11 | 0/3 | 0/3 | 0/3 |
| 5e | n-C6H13 | n-C6H13 | 2/3 | 1/3 | 0/3 |
| 5f | n-C6H13 | n-C7H15 | - | 3/3 | 2/3 |
| 5g | n-C6H13 | n-C8H17 | 3/3 | 2/3 | 0/3 |
| 5h | n-C6H13 | n-C10H21 | 1/3 | 0/3 | 0/3 |
| 5i | n-C6H13 | n-C12H25 | 0/3 | 0/3 | 0/3 |
| 5j | n-C6H13 | n-CH2C6H5 | 2/3 | 1/3 | 0/3 |
| 5k | n-C7H15 | n-C2H5 | 0/3 | 0/3 | 0/3 |
| 5l | n-C7H15 | n-C3H7 | 0/3 | 0/3 | 0/3 |
| 5m | n-C7H15 | n-C4H9 | 1/3 | 0/3 | 0/3 |
| 5n | n-C7H15 | n-C5H11 | 1/3 | 0/3 | 0/3 |
| 5o | n-C7H15 | n-C6H13 | 2/3 | 1/3 | 0/3 |
| 5p | n-C7H15 | n-C7H15 | 3/3 | 2/3 | 1/3 |
| 5q | n-C7H15 | n-C8H17 | 1/3 | 0/3 | 0/3 |
| 5r | n-C7H15 | n-C10H21 | 0/3 | 0/3 | 0/3 |
| 5s | n-C7H15 | n-C12H25 | 0/3 | 0/3 | 0/3 |
| 5t | n-C7H15 | n-CH2C6H5 | 2/3 | 1/3 | 0/3 |
Maximal electroshock: doses of 30, 100 and 200 mg/Kg were administrated intraperitoneally in mice. The animals were examined 0.5 h after administration.
n1/n2: the animals protected / the animals tested.