Table 2.
Quantitative anticonvulsant data in Mice (i.p.).
| Componds | R 1 | R 2 |
ED
50
(mg/kg)
(MES) a |
TD
50
(mg/kg)
(MES) b |
PI c |
|---|---|---|---|---|---|
| 5f | n-C6H13 | n-C7H15 | 37.3(32.4-43.1)d | 422.5(366.2-487.4) | 11.3 |
| 5p | n-C7H13 | n-C7H15 | 41.2(40.0-54.6) | 352.1(305.2-406.2 | 8.5 |
| Carbarmazepine | - | - | 11.8(9.7-14.1) | 76.1(69.1-83.7) | 6.5 |
a
: median effective dose affording anticonvulsant protection in 50% of animals, the dose is measured in mg/Kg.
b
: median toxic dose eliciting minimal neurological toxicity in 50% of animals, the dose is measured in mg/Kg.
c
: protective index (TD50/ED50).
d
: 95% confidence intervals given in parentheses.