Table 3.
Effects of compound 5f on chemical-induced seizures in mice (i.p.).
| Chemical substances | Compound | Doses (mg/Kg) | Test time (h) | Clonic seizures (%) |
Tonic seizures
(%) |
Lethality
(%) |
|---|---|---|---|---|---|---|
| Pentylenetetrazol | DMSO | - | 0.5 | 100 | 100 | 100 |
| Carbamazepine | 50 | 0.5 | 100 | 0 | 10 | |
| 5f | 50 | 0.5 | 100 | 40 | 50 | |
| 3-Mercaptopropionic | DMSO | - | 0.5 | 100 | 100 | 100 |
| acid | Carbamazepine | 50 | 0.5 | 100 | 20 | 10 |
| 5f | 50 | 0.5 | 100 | 20 | 0 | |
| Bicuculline | DMSO | - | 0.5 | 100 | 100 | 100 |
| Carbamazepine | 50 | 0.5 | 100 | 0 | 60 | |
| 5f | 50 | 0.5 | 100 | 0 | 20 |