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. Author manuscript; available in PMC: 2014 Dec 27.
Published in final edited form as: Nat Rev Rheumatol. 2013 Nov 5;9(12):731–740. doi: 10.1038/nrrheum.2013.161

Figure 2.

Figure 2

IL-1β, IL-6, IL-23 and IL-21 shift T cell differentiation towards the Th17 lineage. Th17 cells produce a plethora of cytokines that regulate local and systemic inflammatory effects in GCA.