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Pathogenesis-based therapeutic interventions in GCA
| Currently used | Unexplored |
|---|---|
| Suppression of the IL-6-IL 17 cytokine cluster (corticosteroids) |
Suppression of the IL-12-IFN-γ cytokine cluster |
| Untargeted T cell suppression | Inhibition of immuno-stromal interactions |
| Suppression of dendritic cell stimulation/function |
|
| Suppression of endothelial function | |
| Suppression of VSMC function |
